Research interests

Our Goal

Our research aims to elucidate the molecular mechanisms by which low-grade chronic inflammation—a hallmark of obesity and diabetes—contributes to metabolic dysregulation. By investigating these processes across the tissue, cellular, and organelle levels, we seek to provide foundational knowledge for developing therapeutic strategies for metabolic diseases. Specifically, we focus on understanding the regulatory pathways through which genes associated with metabolic and inflammatory processes affect inter-tissue, intercellular, and inter-organelle communication, with an emphasis on the dysregulated energy metabolism observed in obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD).

● Crosstalk between obesity-induced inflammation and energy metabolism ●

● Obesity-mediated adipose tissue dysfunction and NAFLD pathogenesis ●

● Regulatory mechanism of cell-to-cell interactions in obesity-mediated NAFLD ●

● Roles and regulatory mechanism of Tank-binding kinase 1 (TBK1) in NAFLD ●

● Regulatory mechanisms for ACSL1 localization for hepatic lipid homeostasis ●